What Is Cosmetic Peptides
The cosmetic industry requires a variety of different ingredients for skin care products. These include peptides, growth factors, antioxidants, anti-inflammatory botanicals, and polysaccharides. As these products show drug-like effects they are commonly referred to as cosmeceuticals. Originally, peptides became of interest in cosmetics as a result of the discovery of their beneficial effects in wound healing. As peptides are involved in an immense number of physiological processes, it was logical to further exploit them for cosmetic applications. Most of the peptides used in cosmetics are designed to counteract the aging process of the skin. The need for such products is driven by the increasing desire in modern society to maintain a young appearance even at an older age, and the breadth of possible treatments to achieve this goal. The increasing knowledge about the molecular details of the skin-related aging processes has significantly contributed to the exploration of novel anti-aging agents.
Advantages of Cosmetic Peptides
Reduces fine lines and wrinkles
As people age, collagen and elastin fibers decline, which weakens the skin. As a result, the skin becomes less firm, leading to fine lines and wrinkles.4 in contrast, peptides help smoothen the skin by increasing collagen production and improving elasticity.
Might protect against uv damage
Your skin is a barrier that protects you from the sun's uv rays, microorganisms, and pollution. Some evidence suggests that peptides help support the skin barrier, protecting you from uv damage. In addition to aging, uv exposure also causes fine lines and wrinkles.
May treat acne
Some peptides have antimicrobial properties. In other words, those peptides get rid of microorganisms, like bacteria. Some evidence suggests that antimicrobial peptides help with chronic skin conditions, including acne. When bacteria clog the pores on your skin, your immune system responds. As a result, pimples form on the skin. In contrast, antimicrobial peptides might prevent bacteria from clogging the pores.
Helps heal wounds
Collagen is a key protein in wound healing. Since peptides boost collagen production, some products with peptides may help heal minor injuries. What's more, since some peptides have antimicrobial properties, some evidence suggests that peptides repair the skin while preventing infections. People with trouble healing wounds, like some with diabetes, may benefit from the healing properties of peptides.
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BrightGenix™ GHK-CuINCI name: Copper Trieptide-1 Cas. 89030-95-5 Molecular Formula C14H22CuN6O4 Molecular Weight 400.91 Purity ≥99% Appearance Light blue to blue crystalline powder Production Processread more -
![Anti-winkle Peptides Mu-conotoxin]()
Anti-winkle Peptides Mu-conotoxinINCI Name: µconotoxin CnCIII Cas. 936616-33-0 Molecular Formula C92H139N35O28S6 Molecular Weight 2375.7 Purity ≥95% Appearance White Powder Production Process Chemical synthesisread more -
![Anti-winkle Peptides Hexapeptide-9]()
Anti-winkle Peptides Hexapeptide-9INCI name: Hexapeptide 9 Cas. 1228371-11-6 Molecular Formula C24H38N8O9 Molecular Weight 582.61 Purity ≥98% Appearance White Powder Production Process Chemical synthesisread more -
![PeptiXel™ A-Hexa8]()
PeptiXel™ A-Hexa8INCI name: Acetyl Hexapeptide-8 Cas. 616204-22-9 Molecular Formula C34H60N14O12S Molecular Weight 889 Purity ≥98% Appearance White Powder Production Process Chemical synthesisread more -
![PeptixelTM Anti-winkle Peptides SYN-AKE]()
PeptixelTM Anti-winkle Peptides SYN-AKEINCI name: Dipeptide diaminobutyroyl benzylamide diacetate Cas. 823202-99-9 Molecular Formula C19H29N5O3 Molecular Weight 495.58 Purity ≥98% Appearance White Powder Production Processread more
Our factory
BrightGene Bio-Medical Technology Co., Ltd is a high-end pharmaceutical company with high-barrier intermediates and APls as its core. Founded in 2001, the company has accumulated more than 20 years in the field of characteristic APls and has established core drug R&D technology platforms such as fermentation semi-synthesis, multichiral drugs, non-biological macromolecules, inhalation preparations, and conjugated drugs.
R&D strength
Team: 83 R&D person, 86% of them are bachelor degree or above. Platform: Fully autonomous chassis cell database; Fully autonomous editing tool for screening models.
Production equipment
Research institute has a laboratory area of over 5000 m², with high price advanced analytical equipment like NMR,ICP-MS, & 400M NMR.
Innovation
Synthetic biology drives innovative development in biopharmaceuticals, personal care, and Nutritional Supplements. The company has invested in a large-scale fermentation production line with an annual capacity of hundreds of tons of active ingredients, which is now fully operational. The company has also assembled a professional team focused on the global active ingredients market. The business has expanded rapidly, achieving partnerships and channel development with hundreds of global brands.
Types of Cosmetic Peptides
Signal peptides
Aged skin is, amongst others, characterized by reduced levels of collagen and elastin. Increasing the number of fibroblasts or their collagen production and/or inhibiting further collagen hydrolysis are therefore considered effective means to halt or slow the aging process of the skin. Many of the peptides used in cosmetic preparations are compounds which act on fibroblasts. The n-terminally palmitoylated peptide is marketed under the name of palmitoyloligopeptide and is supposed to penetrate more efficiently through the epidermis than the parent compound. It augments type I and ii collagen and fibronectin production in a dose- and time-dependent manner with no effect on total protein synthesis or on the ratio of secreted proteins to cell-associated proteins.
Neurotransmitter-affecting peptides
Many of the peptides used in cosmetic preparations belong to the group of neurotransmitter-affecting peptides. These peptides act in a similar way as botulinum toxin (botox). By inhibiting signal transduction pathways at neuromuscular junctions they attenuate the formation of wrinkles and fine lines which appear over time due to the repetitive contraction of the intrinsic muscles of facial expression. Botulinum toxin, synthesized by the bacterium clostridium botulinum, is the most potent toxin known. It is a disulfide-linked heterodimer consisting of a heavy and a light chain. Upon binding to the peripheral neuronal presynaptic membrane mediated by the heavy chain the toxin is internalized by receptor-mediated endocytosis. After translocation from the endocytotic vesicle into the cytoplasm, the light chain proteolytically cleaves either snap-25 or synaptobrevin depending on the serological subtype of the neurotoxin. Cleavage of these proteins which are essential for docking to and fusion of acetylcholine vesicles with the inner side of the nerve terminal membrane results in the inhibition of neurotransmitter release at neuromuscular junctions.
Carrier peptides
The tripeptide h-gly-his-lys-oh (ghk) was originally identified in human plasma and has a high affinity for copper2+ (cu2+). It acts as a signaling peptide and a carrier molecule for copper which is a co-factor for several enzymes involved in collagen and elastin formation. The copper peptide was shown to stimulate wound healing but also to reduce fine lines and wrinkles and to improve elasticity and firmness of aged skin. A wide variety of effects have been ascribed to ghk-cu. The peptide exhibits anti-inflammatory actions by suppressing the expression of pro-inflammatory cytokines. It also chemoattracts capillary cells, macrophages and mast cells, increases the synthesis of collagen and elastin, and stimulates the proliferation of fibroblasts and keratinocytes.
Other mechanisms
Many peptides used in cosmetic preparations act by other mechanisms to improve skin appearance or delay skin aging. These include ros scavengers, collagen fiber organizing compounds, and anti-inflammatory peptides: Peptides such as carnosine, anserine and carcinine are histidine dipepeptides with antioxidant activity. Carnosine has been shown to scavenge ros and chelate prooxidative metals. It also inactivates reactive mono- and dialdehydes released during the oxidative breakdown of unsaturated lipids thereby protecting hydrophilic and lipophilic biological molecules from oxidative damage.
Can Cosmetic Peptides Be Used with BHA
It's a common myth that exfoliating skin care ingredients, like alpha hydroxy acids (AHAs) and beta hydroxy acids (BHAs), break down all peptides, rendering them ineffective.
The truth is that there are hundreds of peptides and while some may be vulnerable to this, many will not. When formulated properly with compatible pH levels and stabilization in mind, peptides and skin care acids can (and should) be used together. Each peptide that Paula's Choice chooses to formulate with can be used alongside skin care acids while remaining effective in the pH range that hydroxy acids require to exfoliate skin. Because of this, these hand-selected peptides also remain stable when skin’s pH is temporarily lowered by use of a hydroxy acid-based exfoliant.
However, some acids are particularly adept at breaking down peptides. Strong acids, like hydrochloric acid (a gastric acid found in our digestive system), can break down peptides through a process called acid hydrolysis. Breaking down peptides and other compounds is what these strong acids are designed to do, especially for processes like digesting proteins in the foods we eat.
Before we talk about peptides, it’s important to understand what amino acids are. Peptides are strings of amino acids, which are the building blocks that make up proteins in our body, including collagen in the skin. Without these proteins, we will see wrinkles, brittle nails and dry hair that’s prone to breakage.
Aside from being essential to the skin's structure and function (important factors in firmness, texture and overall appearance), peptides are found in every human cell and play an important role in how the body functions, often acting as a biologic messenger. We need peptides at all times. If we are deficient in them, our body cannot functio. Peptides have a myriad of uses in the body, from being the building blocks for enzymes, hormones and an energy source.
So if peptides are already present within the body, why do we need more of them? The answer, according to experts, is aging. We lose 1% of our remaining collagen per year after age 30. Our skin’s natural communication channels also slow down over time.
But simply slathering peptides onto your skin doesn't necessarily give you more of them. Your body sees these peptides as ‘signals’ that you need to heal, which tells your body to produce more collagen where you need it most. If you are healing from an injury in your ankle, those peptides will signal your body to focus its repair efforts in that joint. If your skin is aging prematurely, those peptides might signal your skin to boost its production of collagen and even hyaluronic acid, plumping up your skin and restoring a healthy skin barrier. When you introduce exogenous peptides onto the skin in the form of a moisturizer or serum, it tricks the skin into thinking there’s been an injury or wound, and it stimulates our collagen-boosting processes.
How to Incorporate Cosmetic Peptides into Your Skincare Routine
So you’ve figured out which type of peptide and product you need for your skin but now what? Wondering what the best way is to add peptides into your routine? Well, you’re in luck! Peptides are incredibly versatile. Here’s how you can seamlessly add peptides into your daily skincare routine:
Morning or evening
Timing is completely up to you! We recommend using them both during the day or night. Use a peptide serum or moisturiser in the morning to protect your skin against daily environmental stressors. Apply a peptide moisturiser at night to seal in hydration so that you wake up with very plump and soft skin.
Prep your canvas
Always begin with a gentle cleanser to remove impurities and prepare your skin to absorb the peptides.
Layer like a pro
If you’re using a peptide serum, apply it after cleansing and toning. Serums are lightweight and designed to penetrate deeply, so they should be applied closest to the skin. Follow up with a peptide-infused cream or your regular moisturiser to seal in the peptides and hydrate the skin further. In the mornings, always finish your routine with a broad spectrum sunscreen with at least spf30.
Consistency is key
Like most skincare, you need to use peptides regularly and for a long period to get the most benefit for for your skin.
Combining with other skincare
Peptides play well most skincare. Examples of successful pairings include peptides with antioxidants like vitamin c for enhanced skin brightness, retinoids for skin ageing or hyaluronic acid for hydration.
Listen to your skin
Whilst peptides are well tolerated by most people, always pay attention to how your skin responds. If irritation occurs, reduce the frequency or if severe, stop using and consult a dermatologist if needed.
About Choosing Cosmetic Peptides Products
There are so many products on the market containing peptides that it can be hard to know where to start. Here’s how to shop for peptides, plus seven skin care brands to consider:
Pick the right form
You’ll want to choose a product like a serum or a moisturizer that has prolonged contact with your skin. A cleanser, for example, won’t be as effective because it’s rinsed off.
Choose other ingredients wisely
Peptides work well in tandem with other ingredients, including vitamin C, niacinamide, antioxidants, and hyaluronic acids. Using a peptide with an alpha hydroxy acid (AHA) will actually make the peptides work less efficiently.
Look at the label
You ideally want to see peptides listed close to the top of the ingredient list. They may also be listed as “palmitoyl.”
Enhance your Beauty Routine with Cosmetic Peptides
Scientific studies have shown promising results when peptides are incorporated into a skincare routine. Peptides exhibit excellent anti-aging properties, strengthen the natural barrier of the skin and add to an overall youthful appearance. Peptides are well tolerated and are therefore suitable for use on sensitive skin types.
Peptides are the body's own protein building blocks. They are made up of amino acid molecules that are connected through peptide bonds. Peptides form part of the hair, connective tissue and nails, and the various forms are found in human and animal cells.
Peptides are considered a true secret weapon in the beauty industry due to their ability to counteract the appearance of wrinkles and other signs of skin aging. It is effective at sending the body signals to stimulate and improve functions such as cellular turnover, cellular vitality and skin renewal which have been scientifically proven in various clinical trials. Cosmetic products that contain peptides are beneficial for mature skin (35 years+). With regular use, these anti-aging wonders lend the complexion a rejuvenated and fresher appearance. If, however, peptide-enriched cosmetics are no longer used, these primary skin concerns may return. We, thus, recommend using peptide-enriched cosmetics continuously. The greatest advantage is that these products are well-tolerated by the skin and suitable for all skin types.
A highly concentrated active ingredient serum provides a visibly firming effect on the facial contours and provides the skin with a high dosage of moisture. The intensive formula contains peptides that boost collagen and elastin as well as hyaluronic acid which is an essential building block for the formation of collagen. Vitamin C in combination with collagen building blocks increases the above-mentioned effect. Intensive moisture provided by hyaluronic acid ensures a more plump and even-looking complexion.
BrightGene Bio-Medical Technology Co., Ltd is a high-end pharmaceutical company with high-barrier intermediates and APls as its core. Founded in 2001, the company has accumulated more than 20 years in the field of characteristic APls and has established core drug R&D technology platforms such as fermentation semi-synthesis, multichiral drugs, non-biological macromolecules, inhalation preparations, and conjugated drugs. Since its development, the company has vertically expanded the industrial chain and extended to the downstream preparation field; horizontally opened up the profit model, and made profits through the investment layout and transfer of biosynthesis and other technologies and the industrialization of large health raw materials.
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As one of the leading cosmetic peptides manufacturers and suppliers in China, we warmly welcome you to wholesale bulk cosmetic peptides in stock here from our factory. All our products are with high quality and competitive price.
Anti aging Peptide Palmitoyl Pentapeptide, 823202-99-9, 616204-22-9