Intermediates

Our factory
BrightGene Bio-Medical Technology Co., Ltd is a high-end pharmaceutical company with high-barrier intermediates and APls as its core. Founded in 2001, the company has accumulated more than 20 years in the field of characteristic APls and has established core drug R&D technology platforms such as fermentation semi-synthesis, multichiral drugs, non-biological macromolecules, inhalation preparations, and conjugated drugs.

R&D strength
Team: 83 R&D person, 86% of them are bachelor degree or above. Platform: Fully autonomous chassis cell database; Fully autonomous editing tool for screening models.

Production equipment
Research institute has a laboratory area of over 5000 m², with high price advanced analytical equipment like NMR,ICP-MS, & 400M NMR.

Innovation
Synthetic biology drives innovative development in biopharmaceuticals, personal care, and Nutritional Supplements. The company has invested in a large-scale fermentation production line with an annual capacity of hundreds of tons of active ingredients, which is now fully operational. The company has also assembled a professional team focused on the global active ingredients market. The business has expanded rapidly, achieving partnerships and channel development with hundreds of global brands.

Based on Chemical Synthesis
In most of the manufacturing processes, you bring about the molecular changes to the raw material molecules to make the products. And it results in molecular conversion. Here the raw material molecules are changed to the product molecules.
But when you’re using chemical reactions to bring about the changes in the molecules, you’re using the power of chemical synthesis. Of course, there’re different types of reactions to make different products. Naturally each reaction has its own process conditions along with the advantages and disadvantages.
You start with using chemical synthesis to make the products. But then the product molecules are still in the reactor along with other undesired molecules.
That’s why you need to isolate them in pure form. And you need suitable separation processes to recover them followed by purification processes to purify them. Because it’s necessary to make them suitable for the customers.

Based on Fermentation Process
With pharmaceutical intermediates especially the advanced intermediates, sometimes the molecules you want to make are too complex. Because of the molecular complexity, the chemical synthesis-based processes fail to achieve required molecular conversion economically. Then you need to think of alternatives like fermentation.
Fermentation process makes use of the power of the microorganisms. Specially developed microorganisms are grown in the fermentors under optimized process conditions in order to make those molecules. Of course, for different products you need different types of microorganisms.
Again, the fermentation process only makes the products. That’s why proper separation and purification processes become essential. This is to recover and purify the products from the fermented broth in order to make them suitable for the customers.
Of course, with pharmaceutical intermediates there’s additional advantage in using fermentation processes. Because the fermentation is a bioprocess, the products made by fermentation are chiral compounds which are difficult to make with chemical synthesis. Additionally, fermentation is a green process alternative.

Based on Enzymatic Reactions
When you study the metabolic processes in the body of the living organisms, you’ll find them to consist of enzymatic reaction. These biochemical processes are catalyzed by enzymes. That’s why enzymes are called biocatalysts.
Because of the advantages, enzymes are made by bioprocesses like fermentation and used as catalysts in molecular synthesis. In fact, when you combine the chemical synthesis and enzymatic reactions, the manufacturing process becomes highly efficient. They’re call chemo-enzymatic processes.
And the chemo-enzymatic processes are powerful enough to make complex pharmaceutical intermediate molecules economically and sustainably.

By Extracting from Natural Sources
If you search for special molecules, you’ll find that natural sources are the best option. Many useful products can be extracted from them.
When you analyze the compositions in the plant kingdom, you’ll be amazed at the product stock. Because the plants make many exotic molecules through enzymatic biochemical processes in the plant cells.
Most of the times, all parts of the plant like leaves, seeds, fruits, flowers, and barks are used to extract useful products. But the product recovery process is very complex. Because the plant feedstocks consist of thousands of molecules, you need proper separation and purification processes to achieve the desired product quality.
As we’ve discussed earlier, the product selection is important especially when you’re talking about the pharmaceutical intermediates.

BrightGene Bio-Medical Technology Co., Ltd is a high-end pharmaceutical company with high-barrier intermediates and APls as its core. Founded in 2001, the company has accumulated more than 20 years in the field of characteristic APls and has established core drug R&D technology platforms such as fermentation semi-synthesis, multichiral drugs, non-biological macromolecules, inhalation preparations, and conjugated drugs. Since its development, the company has vertically expanded the industrial chain and extended to the downstream preparation field; horizontally opened up the profit model, and made profits through the investment layout and transfer of biosynthesis and other technologies and the industrialization of large health raw materials.