Whitevo™HexylRes

UV radiations are known to induce Reactive Oxygen Species (ROS) at the cellular level leading to cellular oxidative stress . Skin cells suffering oxidative stress activates to a certain level the antioxidant machinery comprising Glutathione (GSH) that protects cells from oxidative damage as well as some primary antioxidant enzymes, such as Glutathione Peroxidase (GPX) and Glutathione Reductase (GR) . It has been proven in DNA damage models in human lymphocytes induced by H2O2 that 4-HR administration increased GSH levels but also GPX and GR activities, limiting subsequently oxidative stress and DNA damage . As a phenol derivative, 4-HR, can also donate a proton to free radicals by means of its phenolic hydrogen allowing it to scavenge both peroxyl radical and oxygen superoxide and reduce peroxidation of lipids . Finally, reactive oxygen species may also lead to oxidation reactions of proteins . Due to its amphiphilic character and hydrophilic moiety, 4-HR is able to interact with both with lipids and proteins to efficiently reduce their oxidation.