BGM0504 Injection GLP-1/GIP Receptor Agonist

BGM0504 Injection GLP-1/GIP Receptor Agonist
Details:
Product Name: BGM0504 Injection GLP-1/GIP receptor agonist
  • 2 Indication Type 2 diabetes mellitus; Obesity
  • 1 Type Innovative Drug
  • 3Form Injection
  • 6 Target Dual GLP/GIP receptor agonist
  • 5 Clinical progress Phase Ⅲ clinical trial.
  • 4 Estimated launch time 2027
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Description
Technical Parameters

Product Introduction

 

BGM0504 is patent molecular an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management.

 

R&D Development

 

BGM0504: A Dual Agonist in Clinical Phase Ⅱ

 

Molecule Design: Novel dual agonist with global patent protection

GLP-1R Agonist,confirmed clinical benefits in

● Glycemic control
● Reduced body weight
● Improvement in several cardiovascular risk factors

GIPR agonist, potential benefits in

● Multiple pathways to enhance the efficacy of GLP-1R agonist
● Blocked emesis and attenuates illness-like behaviors elicited by GLP-1R activation.

Pre-clinical Data: Compared to Tirzepatide

Directly compete with Tirzepatide

● CAMP accumulation assay showed that the potency of BGM0504 is approximately 2-fold higher than tirzepatide.
● Demonstrated better efficacy and safety in animal study than tirzepatide. NOAEL values for repeated toxicity were higher than tirzepatide reported.

Clinical Progress: Phase Ⅲ study

● BGM0504 shows superior PK profile compared to tirzepatide in health volunteers with higher exposure.
● BGM0504 shows greater body weight reductions at same close comparing to tirzepatide.
● Finished Phase
● Finished Pharse Ⅱ study and expected to be in Pharse Ⅲ in August 2024.

 

Project Cooperation

 

Technology First

We offer a variety of transmission components

Product License-out

● Biosimilar polypeptide molecules
● Patent formulation tech-package.
● Liscense-out at early/late clinical stage.

Technique License-out

● Client's polypeptide
● Type 1 original drug
● Milestone fee.

 

Certificate Display

 

product-1561-480

 

Exhibition Photos

 

product-1562-559

 

Company Profile

 

product-1561-649

 

 

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